Chinese汉语译成English英语: 凋亡相关基因在大肠高分化腺癌中的表达概况/A Survey of the Expression of Apoptosis-Correlated Genes in Well Differentiated Adenocarcinoma in the Large Intestine
General field: 医学
Detailed field: 医疗（总称） | |
原文文本 - Chinese汉语
凋亡相关基因在大肠高分化腺癌中的表达概况
大肠癌是胃肠道常见的恶性肿瘤，发生率仅次于胃癌，居全球恶性肿瘤第四位[1]。在欧美发达国家,大肠癌位列恶性肿瘤死亡原因的第二位[2]。我国是大肠癌发病率相对低的国家之一,但近年来呈上升趋势，并在我国大部分地区已经成为发病率上升最快的恶性肿瘤之一。临床治疗仍以手术为主，辅以放化疗。在大肠癌早期的病人中手术治愈率可达到80%且5年生存率较高。相比较而言，中晚期病人术后常常对放化疗药物不敏感，以及局部肿瘤再发、肝脏转移是其预后不良的主要因素[3]。因此，大肠癌防治的关键在于早期预防、早期诊断与复发转移的早期监测。近些年对于肿瘤病因、发病机制的深入研究，细胞凋亡调节异常是肿瘤发生和发展的重要机制。随着基础研究与临床实践的紧密结合，利用大肠癌细胞凋亡机制进行细胞凋亡因子检测和细胞凋亡诱导治疗成为大肠癌早期诊断和治疗研究领域的热点课题。
| 翻译文本 - English英语
A Survey of the Expression of Apoptosis-Correlated Genes in Well Differentiated Adenocarcinoma in the Large Intestine
Colorectal carcinoma is a commonly seen malignant tumor of the gastrointestinal tract, with rates second only to gastric carcinoma, and fourth among cancers worldwide [1].In the developed countries of Europe and America, colorectal cancer is the second largest cause of death due to cancer [2].China is a country with a comparatively low incidence of colorectal cancer, but in recent years there has been a rise in colorectal cancer rates, and most areas in China already exhibit some of the fastest growing cancer rates. Surgery remains the primary form of clinical treatment, supplementing radio-chemotherapy. The recovery rate of early stage colorectal cancer patients who undergo surgery is relatively high with a 5-year survival rate of as high as 80%. Comparatively speaking, late stage cancer patients are not as sensitive to radio-chemotherapy after surgery and local tumor recurrence and liver metastasis are primary negative factors affecting their prognosis [3]. Considering, it follows that the key to treatment and prevention of colorectal cancer lies in early stage prophylaxis, early diagnosis, and monitoring for metastasis and/or relapse in their early stages. In recent years tumor pathogenesis has undergone significant research, and abnormalities in regulation of apoptosis has been identified as an important mechanism of tumor formation and development. Due to the fundamental inseparability of research and clinical practice, use of the apoptosis mechanisms in colorectal cancer cells to detect cell apoptosis factors and explore apoptosis based treatments has become an area of increased interest for research of colorectal cancer diagnosis and treatment.
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翻译样本