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Spanish to English: Abstract on Alzheimer General field: Medical Detailed field: Medical (general)
Source text - Spanish RESUMEN
El Alzheimer es una enfermedad neurodegenerativa de alta prevalencia, que afecta principalmente a individuos de la tercera edad. Su principal agente neurotóxico corresponde a oligómeros del péptido β-amiloide (Aβ). En la actualidad, no hay tratamientos que tengan como blanco terapéutico el principal agente neurotóxico de la enfermedad. Por esto, nuestro laboratorio identificó un pentapeptido derivado de la región C-terminal de Aβ, G33LMVG37, que bloquea la agregación, asociación, sinaptotóxicidad y perforación de membrana plasmática inducida por Aβ. Sin embargo, como el uso de péptidos en terapias farmacológicas posee ciertas complicaciones, se planteó la posibilidad de utilizar moléculas pequeñas peptidomiméticas que interaccionen con la región C terminal de Aβ. En este contexto, se seleccionaron Peptidomiméticos que fueron evaluados a nivel in silico e in vitro. Los resultados obtenidos mostraron que el Peptidomimético M30 bloquea los efectos tóxicos que induce Aβ en el aumento de calcio intracelular, sinaptotoxicidad y supervivencia celular. En base a estos antecedentes, se propone que el Peptidomimético M30, derivado del pentapeptido G33LMVG37, actúa como inhibidor de la toxicidad del péptido β-amiloide en modelos funcionales sinápticos e in vivo. A partir de esto, en el presente trabajo se evaluó el efecto de M30 como inhibidor de la toxicidad sináptica producida por Aβ en neuronas del hipocampo, y se estudió el efecto de M30 sobre un modelo de adquisición de memoria in vivo. Los resultados indican que M30 inhibe la toxicidad sináptica de Aβ y fomenta la actividad de la red neuronal espontanea, tal vez aumentando el número de sinapsis activas o la funcionalidad de red neuronal en neuronas del hipocampo de ratones, mientras que en los ensayos in vivo Barnes Maze, los ratones con esterotaxia de Aβ más la molécula lograron un comportamiento de memoria espacial muy similar al grupo control, con un mayor porcentaje de aciertos positivos que los ratones con esterotaxia de Aβ, por lo que se concluye que la molécula M30 inhibe el daño neuronal a nivel de memoria espacial en un estudio de comportamiento Barnes Maze. En resumen, los resultados de este estudio proporcionan información que puede ser útil para seguir sentando bases en la investigación para el uso del M30 como posible inhibidor del péptido Aβ en la enfermedad de Alzheimer.
Translation - English Abstract
Alzheimer is a highly prevalent neurodegenerative disease that mainly affects the elderly. Its main neurotoxic agent corresponds to oligomers of the β-amyloid (Aβ) peptide. Currently, there are no treatments that target the main neurotoxic agent of the disease. Therefore, our laboratory identified a pentapeptide derived from the C-terminal region of Aβ, G33LMVG37, which blocks the insertion, association, synaptotoxicity and plasma membrane perforation induced by Aβ. However, since the use of peptides in pharmacological therapies can carry certain complications, the possibility of using small peptidomimetic molecules that interact with the C-terminal region of Aβ was considered. In this context, peptidomimetics evaluated at an in silico an in vitro levels were selected. The obtained results showed that Peptidomimetic M30 blocks the toxic effects induced by Aβ in the increase of intracellular calcium, synaptoxicity and cell survival. Against this background, it is proposed that Peptidomimetic M30, derived from pentapeptide G33LMVG37, acts as an inhibitor of the toxicity of the β-amyloid peptide, both in synaptic and in vivo functional models. Based on this data, this work evaluates the effect of M30 as an inhibitor of synaptic toxicity produced by Aβ in hippocampal neurons, and studies the effect of M30 on an in vivo memory acquisition model. The results indicate that M30 inhibits the synaptic toxicity of Aβ and promotes the spontaneous neural network activity, perhaps by increasing the number of active synapses or the functionality of the neural network in the hippocampal neurons of mice; while in the Barnes Maze in vivo assays, mice with Aβ stereotaxy plus M30 molecule achieved a very similar spatial memory behavior to the control group, with a higher percentage of positive hits than mice with Aβ stereotaxy, thus helping to conclude that the M30 molecule inhibits neuronal damage at a spatial memory level in a Barnes Maze behavioral study. In summary, the results of this study provide information that may be useful in furthering the research basis for the use of M30 as a possible Aβ-peptide inhibitor in Alzheimer's disease.
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I'm a licensed english, german and spanish translator. I got my degree at University of Concepción, in Chile. For the past 2 years, I've been working as a freelancer with different people from my country, but particulary with people from the University itself. I've also worked translating papers (to be published) and class materials for profesors from other universities, who seek me out due to my work methodology.
As of now, I possess vast experience when translating texts from fields such as linguistics, maths, defense and military, oenology related texts, physics, astronomy. I can get my head around legal and other related stuff.
I can proficiently translate from spanish to english, english to spanish an german to both, spanish and english. When the translation work demands it, I like to take at least a day to read documents related to the field in which I'm about to embark (for example, when it's about maths or physics, I like to check out first wheter or not I'm capable of offering a good translation, and would rather pass out the opportunity if I feel myself way over my head).
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