George Rabel (asker) May 20, 2021:

I appreciate the help. I received official confirmation that "across 4 doses" meant that similar results were observed after the administration of either of the 4 different concentrations over a period of several weeks. Unfortunately, neither of the two answers are correct, so I cannot award KudoZ. They do, however, confirm that there is good reason to be confused by that verbiage.

Eduardo Martins May 11, 2021:

After giving my answer and reading the discussion, I gave a second look about this and I think "throughout" can be your answer.

Jenna Porter-Jacek May 10, 2021:

I think your second thought ("another possibility") is correct. Here is an example from a website on Trulicity (https://www.trulicity.com/hcp)

"Powerful A1C reduction across 4 doses...
...In clinical studies, the mean A1C reduction from baseline at primary endpoint was 0.7% to 1.6% for the 0.75 mg dose and 0.8% to 1.6% for the 1.5 mg dose. In a clinical study, the mean A1C reduction from baseline was 1.5% for the 1.5 mg dose (active control); 1.6% for the 3.0 mg dose; and 1.8% for the 4.5 mg dose."


The clinical trial used 4 different doses (concentrations) of the drug, and all doses (concentrations) saw a reduction in A1c.

George Rabel (asker) May 10, 2021:

another possibility The medication in question is available in 4 different concentrations or "dosis." The statement could be saying that the quoted result was achieved with either of the 4 different concentrations. I was intent on interpreting the word "doses" as "application" rather than "concentration."

George Rabel (asker) May 10, 2021:

The only other possible meaning I can think of... ...is that "across 4 doses" means after either 1, 2, 3 or 4 doses, but that strikes me as highly unlikely.