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原文文本 - English英语 No more than 100 subjects will be enrolled consecutively on the basis that significant efficacy has been observed in cohort 1, the nasopharyngeal carcinoma cohort. The target number of subjects is adjusted to 40 due to the slow enrollment in cohort 2. Therefore, the overall population of the study increased from 568 to 574. On the basis of the results of safety and pharmacokinetic data in the previous phase I study of AAA, 20 mg/kg is determined as the recommended dose of the 2-week monotherapy regimen, and no study on the 100 mg/kg cohorts will be conducted anymore. Data Safety Monitoring Committee (DSMC) plan on the dataset and Dose-Limiting Toxicity (DLT) observations are deleted accordingly. Disease background of gastric carcinoma, esophageal carcinoma, nasopharyngeal carcinoma and head and neck squamous cell carcinoma and the rationale for study design, theoretical basis emphasizing the AAA as monotherapy, rationale allowing subjects to continue AAA treatment after disease progression and the scientificity of conducting a selectable biomarkers study are added.
原文文本 - English英语 It was reported that the procedure was to treat a lesion in the proximal circumflex artery with heavy calcification, and 80% stenosis. A 2.0x20mm XXX balloon dilatation catheter (BDC) was soaked prior to use and air aspiration was not performed outside of the patient anatomy prior to use. The BDC was advanced and the balloon was inflated two times to 8 atmospheres for 5 seconds. However, when the BDC was intended to be deflated negative pressure was held for about 10 seconds, all of the air could not be removed and the balloon could not refold. The XXX BDC was removed; however, resistance was met with the guiding catheter and force was applied to remove the BDC. Another 2.0x20mm XXX BDC was used to ultimately treat the target lesion. Post stenosis was 5%. There was no adverse patient effect and no clinically significant delay in the procedure.
Factors that may contribute to difficulty deflating the catheter may include, but are not limited to: deflation technique, contrast concentration, tortuous anatomy, loose connection with the indeflator, and contamination in the inflation lumen or damage to the guide wire and/or inflation lumen. Returned device analysis noted the outer member was stretched near the mid-lap seal which suggests tensile overload possibly as a result of resistance during removal of the protective sheath or during use; however this cannot be determined. If the stretching was present prior to attempting to deflate the balloon, this would contribute to a slower deflation when pulling a negative and the balloon be returned flat. The reported incomplete deflation of the balloon would likely result in the resistance during removal from the guiding catheter. Based on the information reviewed, a conclusive cause for the reported deflation difficulties cannot be determined and the reported resistance during removal from the guiding catheter appears to be due to operation context of the procedure. Based on the information reviewed, there is no indication the issue was caused by, or related to the design, manufacture, or labeling of the device.
When undergoing hemodiafiltration for the first time, or during the early periods of hemodiafiltration or when replacing dialyzers, patients shall be carefully observed for possible signs or symptoms including but not limited to chest and back pain, and proper measures shall be taken. And if these signs or symptoms are not alleviated, hemodiafiltration shall be terminated. If patients experience other possible signs or symptoms including but not limited to itchy skin, hives, cough, sneezing, a clear runny nose, abdominal pain and diarrhea, difficulty in breathing and shock, hemodiafiltration shall be terminated immediately.
Preparation
The operator shall read the Instructions for Use carefully before usage and understand the requirements imposed on operation by different dialyzer membranes and sterilization methods.
Priming
1. Remove the product’s outer packaging, place the dialyzer vertically in the holder (venous end up), and connect the dialyzer to the extracorporeal blood circuit one blood port at a time (while keeping the dust caps of the dialysate ports sealed). As with any ordinary blood circuit connection, achieve a co-current flow and measure the blood pressures at the dialyzer blood ports and circuit patient ends.
2. Saline solution can be used to prime the dialyzer by gravity or using the blood pump. Usually 1000mL of saline will used in the priming.
3. Priming the dialysate compartment: When the machine’s self-tests are successfully completed, attach the dialysate lines to the dialyzer to prime the dialysate compartment.
4. Recirculate the extracorporeal circuit for 5-10 minutes or start isolated ultrafiltration, setting removed fluid volume at 100-200ml (to prime the dialysate compartment), after whose completion prepare for treatment.
Initiation
1. Set the treatment parameters and select the treatment mode (HDF) following the patient’s doctor’s suggestions.
2. Press the treatment button and enter the blood flow interface, when blood pump speed will get to 100mL/min automatically. When blood start to flow into the venous drip chamber, connects the patient end of the venous line to the needle, increase pump speed, and dialysis is started. If the treatment is HDF, start dialysis after pump speed reaches the target blood flow level.
3. Monitor all data following the specifications and requirements of hemodialysis health care and respond accordingly.
Termination
1. At the completion of treatment, the pump will stop automatically. Start the pump after the circuit is closed, and pump speed will automatically get to 100mL/min, which allows the blood to be reinfused.
2. At the completion of blood reinfusion, disconnect the venous connector from the patient and connect it to the machine, which will automatically start draining the dialysate and jumps to the disinfection interface.
3. Conduct good post-dialysis care and medical device disinfection following the specifications and requirements of hemodialysis health care.
Chinese汉语译成English英语: 仙侠网络小说 General field: 艺术/文学 Detailed field: 诗词与文学
翻译文本 - English英语 Yu Su came to a sudden realization: “You fear it will fall into the hands of wrong people and the result will be catastrophic.”
There was a hiss. “The nine kingdoms have no shortage of fighting masters. Other than Wuqing Bin, no one will be able to resist the nine kings working together even if he finds the dormant demon god. What worries me is that once the demon surfaces, the other demon gods can sense it and they will descend upon the nine kingdom. And that, my friend, is the real apocalypse.
“Ok, one last question.” Yu was nonchalant. “Why me? Wushuang Zhan fits the role better.”
When Yu thought of Zhan, he always heard a voice in his head. The voice would repeat what people had been saying about Zhan:
A true king has been born.
He will be undefeated in his life,
and no one can call himself his equal.
“Because you are the same as me.” Qilin Shen’s voice was filled with emotion.
“Then, let, us, begin.” The shadow conjured up by Shen was light enough to see through, and was about to scatter.
A piece of purple crystal gradually emerged from the black smog and floated towards the space over Yu’s calvaria.
With an icy sensation, the crystal sank into Yu’s calvaria and appeared in the soul.
Seeing from afar, close to the sacred Nine Dragon Chinese Cauldron, there was a piece of crystal the size of a thumb giving out a pale purple light.
The black smog shadow of Shen was taken aback. His shock cut deep: “That cauldron is…”
“I see. Hahaha… It turns out that I’m the one not worthy enough…” Shen tilted his head backwards and laughed, as if finding out some great secret for the first time.
“It is good it has turned out this way. It’s merely the Tower of Warriors. With this cauldron in your hands, I have no doubt trusting you with the tower…”
“Kid, see you in the next life.”
Shen’s smog grew lighter and lighter, dancing back and forth on his dead body, lingering and alone.
A fox dies with his head facing his cave. When it dies, even the spirit has difficulty letting go of the body.
Sorrow trickled out of Yu’s heart. The last flume of spirit of a god in the nine kingdoms had been destroyed, and he was truly gone now.
Yu pushed up his sleeves, took a bow, and knelt.
“Guru, rest in peace.”
It was empty around and the moon glowed white. Yu fell into a long silence, at the end of which he finally whispered: “Is the rabbit mourning the fox? Show yourself, Wuqing Bin, or shall I call you Lang Lin?”
A long whistling sound…
A pale phantom rose quietly where Shen’s body lay, and where his spirit scattered.
English英语译成Chinese汉语: Colon Cancer Treatment Options General field: 医学 Detailed field: 医疗（总称）
原文文本 - English英语 All cases of metachronous or synchronous metastatic colon cancer with potentially resectable liver metastases should be presented at a CRC tumor board with representation from colorectal surgery, liver surgery and medical oncology.
Delineating any limited resectable liver metastases that do not require tumor response for optimal resection would be left to the tumor board.
Synchronous Metastatic Colon Cancer to the Liver That Is Potentially Resectable
Symptomatic primary: Symptomatic primary tumor is defined as obstruction, bleeding or perforation requiring urgent resection or management of the primary tumor. In this case, the first step is to resect the primary tumor or divert with the creation of a temporary colostomy or ileostomy.
* Limited resectable liver metastases: Resection of both primary and liver metastases in a one-stage operation is preferred. Those who are eligible for postoperative chemotherapy should be treated with an oxaliplatin-based chemotherapy regimen (or 5-fluorouracil / capecitabine if oxaliplatin is contraindicated) for up to six months.
* Nonlimited resectable liver metastases: Diversion can be associated with a shorter recovery time and is preferred to resection, given preference for upfront chemotherapy. After diversion or resection, combination chemotherapy is recommended for up to three months to minimize hepatic chemotherapy toxicity (see rules of chemotherapy regimen selection below). This is to be followed by attempted one- or two-stage resection of liver metastases and/or primary tumor.
* After resection with no evidence of disease (NED) status, combination chemotherapy, preferably with an oxaliplatin-based regimen, is recommended for up to three months (total perioperative chemotherapy up to six months).
翻译文本 - English英语 A CT-Based Morphometric Analysis of the Articular Facets of Atlantoaxial Lateral Masses for Better Fusion Cage Design
Abstract
Objective: The objective of this study is to evaluate the morphometric parameters of articular facets of the atlantoaxial lateral masses in the hope that it may provide some input for the design of an atlantoaxial lateral mass fusion cage.
Methods: This is a retrospective study. A sample of 100 healthy adults who had undergone a cervical CT scan between January 2019 and June 2020 in Ningbo No. 6 Hospital (hereafter referred to as “the Hospital”) was selected retrospectively. The sample consisted of 57 males and 43 females with ages between 26 and 61 years and an average age of 40.9 ± 6.4 years. A Philips 64-slice CT scanner was used to scan the subjects’ C1-C7 vertebrae and reconstruct two-dimensional images. The curvatures and lengths of, and intervertebral distances between the Facets were measured in the sagittal and coronal planes, and measurements for the left and right Facets were compared. Also, the contours of the Facets and the distribution of vertices of concavities and convexities (if the Facet was concave or convex) were studied.
Results: There were no statistically significant differences between the curvatures and lengths of, and intervertebral distances between the left and right Facets (a mean p-value > 0.05) in neither the sagittal nor the coronal plane, therefore the two datasets were merged. The curvatures of atlantal and axial facets were (171.16° ± 6.21°) and (166.37° ± 8.50°) respectively in the sagittal plane, and (159.83° ± 8.22°) and (167.22° ± 10.40°) respectively in the coronal plane. The lengths of atlantal and axial facets were (16.38±1.61) mm and (16.59±1.63) mm respectively in the sagittal plane and (16.7±1.61) mm and (17.14±1.69) mm in the coronal plane. The anterior, middle, and posterior intervertebral distances between the Facets were (2.87 ± 0.80) mm, (2.22 ± 0.63) mm, and (3.25 ± 1.00) mm respectively in the sagittal plane and the inside, middle, and outside intervertebral distances between the Facets were (1.94 ± 0.74) mm, (3.39 ± 0.57) mm and (1.64 ± 0.62) mm respectively in the coronal plane. Contours of the Facets in the sagittal plane were mostly either both convex, or one being convex and the other being flat; while the Facets in the coronal plane were mostly either both concave or one being concave and the other being flat. Moreover, the vertices of the contours were mostly in the middle third of the Facets in the sagittal plane, and mostly outside the middle third in the coronal plane.
Conclusion: Lengths of, intervertebral distances between, and curvatures of the Facets and the positions of their vertices both in the sagittal and coronal planes shall all be taken into account in the design of an atlantoaxial lateral mass fusion cage to improve its clinical outcome.
Research funder: Natural Science Foundation of Ningbo (Grant/Award number: 2019A610249)
Literature Review
Posterior atlantoaxial internal fixation using a rod and screw construct combined with posterior atlantoaxial arthrodesis or fusion using bone graft is currently the main surgical approach to treat atlantoaxial instability1-2. However, atlantoaxial fusion merely pads the space between the altas posterior arch and the axial lamina with bone graft without any fixation or compression needed for stabilization, leading to a relatively high failure rate3. Moreover, atlantoaxial fusion is not possible for patients with congenital absence of the atlas posterior arch or who need to have their atlas posterior arch removed. Goel et al.4 provided an alternative technique for posterior atlantoaxial fusion by the forcible placement of a spiked titanium metal joint spacer in addition to bone graft pieces. The studies of Li et al. and Park et al. confirmed the biomechanic stability of a posterior rod and screw construct combined with an intervertebral fusion cage. The Facets have various morphologies, however, the intervertebral fusion cages reported by current literature all have flat surfaces and don’t have curvatures in the coronal and sagittal planes, which makes it very hard for them to completely attach to the Facets, resulting in decreased fusion cage stability and bone graft fusion rate. At present, a morphological study of the curvatures of the Facets cannot be found in literature either in China or abroad. This study performed morphometric measurements and analysis of the Facets in healthy adults using thin-slice CT scanning in the hope that it may provide some input for the optimization of atlantoaxial lateral mass fusion cage design.
Chinese汉语译成English英语: 全球探宝：从身无分文到亿万富翁 General field: 艺术/文学 Detailed field: 诗词与文学
翻译文本 - English英语 Chapter 172 A Concerted Effort
Staring at the opening in the monolith, Ashton Chamber was as cool as a cucumber, but a storm was raging in his heart.
For what lay behind the opening, people had come to kill him. For what lay behind the opening, he had spent an absurd amount of money on killing those trying to kill him. For what lay behind the opening, he had spent months scheming and planning. It was finally within reach.
He wanted to howl at the top of his lungs to give vent to his long-suppressed passions, but it wasn’t the right time or place, so he checked himself, feeling the eyes of the 400-plus mercenaries burning on him.
“Everyone, take a barrel. Let’s go.”
Ashton shouted the order.
Wearing a light on their heads and dragging a barrel in their hands, the mercenaries rushed toward inside the opening as if they were in a charge to storm a stronghold.
Ashton had already had the air tested. It was putrid but there was enough oxygen. And there weren’t any poisonous gases or deadly organisms like in the movies.
Ashton followed the mercenaries and took his time getting in. The long passageway was not a straight line but meandered, and was dark and full of booby traps.
But thousands of years had passed, and the wooden traps had become rotten, the stone ones jammed for various reasons and they no longer worked.
At the end of the 6-foot wide passageway was a big hall. The hall seemed natural and had a high dome.
The hall was about the size of 2 football fields, and in it, there were heaps of gold the sizes of mounds.
It was exactly what Ashton had seen with the Eye of Truth: there were gold coins and ingots,
and the hall had no other opening and there wasn’t much dust on the gold.
Treasures beyond count were scattered and heaped almost carelessly, with only a small part of them in bronze-framed wooden chests.
The wood of the chests was rotten as well, and one would fear that a single touch would reduce it to ashes.
The mercenaries stood in silence watching, the lights on their heads shone on the mounds of gold from all angles and the mounds gave a golden, intoxicating shimmer.
Their eyes were eager and hearts pounding faster, but they stood still and straight.
They were tempted by the towering gold, but they remembered their training as a soldier.
Ashton strode leisurely forward to the mounds, grasped a handful of coins, turned his palm upward, opened it, and let the coins slide through the cracks between his fingers.
The coins fell onto the heap and clinked one by one.
He could no longer contain himself and burst out laughing. “Hahaha…Guys, move it.
Put all the gold in the barrels.”
The mercenaries swarmed forward, and picked and grasped and scooped and held to their chests, loading up the barrels with gold.
The hall started to be filled with clinks and clanks and people shouting, laughing, and chattering.
Joe Gogh shouted in a thundering voice, “Don’t fill the barrel to the brim, leave it a third empty or the forklift won’t lift.”
Fearing that some might not be able to hear him, he shifted places and repeated what he had said.
“Be careful or you’ll break the barrel.”
“Slower. Gold is heavy. Don’t hurt yourself.”
“Remember you reflect on the team. Don’t tarnish its good name.”
A handful of company commanders barked orders at the back and reminded the mercenaries of safety precautions.
Meanwhile, Ashton led Joseph Price and Joe Gogh to the stone chambers on the side of the hall, dragging a handful of barrels behind them.
Those chambers seemed to be man-made and were well hidden, but not to the Eye of Truth.
Inside those chambers were exquisite gold artifacts such as delicately shaped kettles,
vases with hollow patterns on the surfaces, candlestands with etched flowers. And they were all made of gold.
Ashton kind of grew fond of King Solomon, namely, of his appetite for collecting gold.
Because his collection, which had taken a lifetime to accumulate, and the contributions from his vassal states all belonged to Ashton Chamber now.
The three worked together to put the gold artifacts into the barrels extra carefully, including the gold crown inlaid with a ruby.
When they were out of the chamber and back in the hall, the mercenaries had finished loading.
100 metric tons of gold, valuable as they were, didn’t take much space.
There were 400 barrels, and a barrel held a quarter of a ton of gold on average.
The mercenaries moved fast as they did in battles, like wildfire.
It only took them half an hour to load mounds of gold into barrels.
A company commander drove a forklift along the passageway into the hall. The forklift was more than 3-feet wide but didn’t even hit a bump in the meandering but smooth tunnel.
Several people lifted one end of a barrel and the forklift lowered its fork, extended it slowly, and lifted the barrel.
It turned around skillfully and drove out in a rush.
Joe Gogh suggested to Ashton, “Mr. Chamber, let’s get some ropes and have the guys carry them out.”
4 persons a barrel and it would only take a handful of trips to get all the barrels outside.
Ashton thought the plan was somewhat feasible but raised his doubt, “If they carry with hands, it will take 6, 7 people to carry a barrel, and the passage is not wide enough.
If they carry on shoulders, we don’t have enough ropes.
And it’s nighttime in Agren, there is nowhere to buy ropes.”
Joe Gogh thought for a moment and said, “There is another way. We can get more barrels and redistribute the gold in the barrels, but it will take time.”
The usually quiet Joseph Price opened his mouth,
“If we can’t carry them, we can roll them.”
Not understanding Price, Gogh was about to lose his temper, but Ashton’s chuckle made him see what Price meant in an instant.
“Right! The barrel is a cylinder and if we lay them down,
we can roll them out.” Thought Gogh.
Gogh was excited and shouted, “Guys, fasten the lid. Make it super fast.
And push the barrel down and roll it. 4 men a barrel. Roll it slowly outside.”
The mercenaries stood in rows of four behind the barrels and started to roll the barrels outside, slowly but steadily.
It took them several trips and over an hour, but they finally got all
the barrels loaded with gold to the assembly workshop and stacked them in the corners neatly.
The gold artifacts in the stone chambers were carried out by the forklift, carefully and slowly, and placed beside the gold coins and ingots.
Gogh was about to order the mercenaries to stand in formation, strip, and change into clean clothes, to prove they didn’t steal anything.
But Ashton stopped him and said, “That won’t be necessary. I trust the guys and they are worthy of my trust.”
But the truth was Ashton had already checked each one of them with the Eye of Truth.
These mercenaries, though all having a lust for money, had kept their principles and honor and won Ashton’s respect.
Not one of them stole the gold. They even kept their hands out of pocket the entire time to avoid suspicion.
Ashton continued, “Now stage one of the assignment is completed. Clean up the assembly workshop.
You are divided into two shifts. The first shift stays to keep guard, and the second shift gets out and cleans yourselves up in the river outside.
Most importantly, remember, after you go outside, keep your mouth shut and everything to yourself.”
A cacophony of cheers broke out and half of the mercenaries swarmed outside and jumped into the Ava River out of excitement.
Even those who couldn’t swim took off their clothes got into the shallow parts and emerged their bodies in the cold water.
They needed it to calm their minds and put a close to a night of delirious agitation and feverish excitement.
·Graduated with a B.A. in English literature from China’s
3rd ranking Zhejiang University ·1 year’s experience in Chinese to English web fiction translation
·3 years’ experience in medical translation ·4 years’ experience in software engineering ·4 years’ experience in financial news reporting and financial translation ·3 years’ experience in construction and power engineering ·Expert in Trados and memoQ
关键词： medical translator, medical paper translator, clinical trial translator, medical device translator, cardiology translator, oncology translator, orthopedics translator, 医学翻译，医学论文翻译, 临床试验翻译，医疗器械翻译，心脏内科翻译，心脏外科翻译，肿瘤科翻译，骨科翻译
翻译样本 