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It will be my pleasure to be of assistance by provide you the highest quality phone, video and onsite interpreting or translation, as I did for Children’s Hospital of Philadelphia, University of Pennsylvania, Johns Hopkins Hospital and many more clients
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服务
Translation, Interpreting, Editing/proofreading, Training
English英语译成Chinese汉语: Phosphatase and tensin homolog inhibit malignant transformation and suppress tumor growth General field: 医学 Detailed field: 医疗：医疗服务
原文文本 - English英语 PTEN (phosphate and tensin homology deleted on chromose ten)基因是一种新型肿瘤抑制基因，研究发现其在维持细胞的增殖、分化和凋亡平衡中起重要作用，并可能参与调节细胞生长，肿瘤浸润、转移和血管形成[4, 5]。研究发现：PTEN抑制肿瘤发生的机制是通过使PIP3（磷酯酰肌醇-3-磷酸）去磷酸化而抑制磷酯酰肌醇-3-磷酸(PIP3)途径，最终达到阻止细胞生长及促进细胞凋亡的目的[4, 5]。PTEN基因的失活，可能引起细胞过度增殖及凋亡减少，从而导致了肿瘤的生长和转化。研究人员的研究结果证实了PTEN基因的失活与人类许多恶性肿瘤的发生有关，李锦毅等[6]研究结果显示，PTEN mRNA在非癌粘膜、早期胃癌、进展期胃癌阳性表达率分别为76.3%，45.5%，34.2%；其蛋白的阳性表达率为100%，63.6%，47.4%，此结果提示PTEN基因异常表达参与胃癌上皮细胞的恶性转化。本研究结果显示，在食管正常粘膜中PTEN蛋白的阳性表达在癌组织中明显低于癌旁正常食管粘膜，差异有显著的统计学意义(P
翻译文本 - Chinese汉语 Phosphatase and tensin homolog (PTEN, once named phosphatase and tensin homolog deleted on chromosome ten) is a newly identified tumor suppressor gene which has been shown to play important roles not only in cell proliferation, differentiation and apoptosis, but also potentially in the regulation of cell growth, tumor infiltration, metastasis and angiogenesis [4,5].
Recent studies have revealed several putative mechanisms relating to tumor suppression. First, PTEN inhibits the phosphatidylinositol-3-phosphate (PIP3) pathway by dephosphorylating PIP3, ultimately preventing cell growth and promoting cell apoptosis [4,5]. Correspondingly, inactivation of the PTEN gene can result in over-proliferation of cells and decreased apoptosis, facilitating tumor growth and transformation.
Second, PTEN can also significantly inhibit adhesions, facilitate migration and spread of a variety of tumor cells, thus closely linking PTEN loss to tumor invasion and metastasis [7]. Studies have shown that PTEN inhibits cell infiltration and metastasis by dephosphorylating focal adhesion kinase (FAK) which plays critical roles in tumor invasion and metastasis, thus inhibiting cell proliferation, cell adhesion, migration, and local spread [8]. Both in vitro and in vivo studies have shown FAK dephosphorylation by PTEN with PTEN overexpression consequentially inhibiting integrin-mediated cell expansion, focal adhesion formation, and cell migration. The findings are supported by antisense study in which knockdown of PTEN enhanced cell migration. Additionally, FAK overexpression antagonized the effects of inhibition of PTEN on tumor cell infiltration and metastasis. Several groups [4,5,10] observed that, in liver cancer cells SMMC-7721 treated with TGF-β1 (transforming growth factor beta 1), integrin α5β1 expression was significantly elevated while PTEN protein expression was significantly decreased, which led to dramatically enhanced phosphorylation of FAK, and enhanced adhesion and migration to fibronectin/laminin of the extracellular matrix.
A study led by Jinyi Li et al. suggests that PTEN gene inactivation correlates with the occurrence of many human malignancies [6]. In non-cancerous mucosa, early gastric cancer, and advanced gastric cancer, PTEN were detected as 76.3% , 45.5% and 34.2% at mRNA level and 100%, 63.6% and 47.4% at protein level, respectively, suggesting abnormal expression of the PTEN gene was involved in the malignant transformation of gastric epithelial cells. This study also found that PTEN protein expression in cancer tissue was significantly lower than that in surrounding normal mucosal tissue in esophageal mucosa (P
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翻译相关教育经历
Master's degree - Johns Hopkins University (Maryland, USA)
English英语译成Chinese汉语 (Educational Testing Service - TOEFL) English英语译成Chinese汉语 (GRE) English英语译成Chinese汉语 (American Translators Association) English英语译成Chinese汉语 (National Board of Certification for Medical Interpreters) English英语译成Chinese汉语 (ECFMG)
Chinese汉语译成English英语 (National Board of Certification for Medical Interpreters) Chinese汉语译成English英语 (American Translators Association) Chinese汉语译成English英语 (Educational Testing Service - TOEFL) Chinese汉语译成English英语 (GRE) Chinese汉语译成English英语 (ECFMG)
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会籍
ATA, International Medical Interpreters Association: IMIA, International Medical Interpreters Association: IMIA
软件
Adobe Acrobat, Adobe Photoshop, Google Translator Toolkit, Microsoft Excel, Microsoft Office Pro, Microsoft Word, Powerpoint, Trados Studio
档案
1. Medical school in China followed by post-graduate training at Johns Hopkins University;
2. Native speaker of Chinese, passed English tests of TOEFL, GRE (full score) and United States Medical Licensing Examination (USMLE)
3. Publication in high impact medical journals (Journal of Clinical Investigation, Cancer Cell, Cancer Research….)
4. Licensed to practice medicine in both China (physician) and USA (CMI)
5. It will be my pleasure to be of assistance by provide you the highest quality phone, video, and onsite interpreting, translation and localization, as I did for Children’s Hospital of Philadelphia, Hospital of University of Pennsylvania, Johns Hopkins Hospital, Temple University, Thomas Jefferson University, and many more clients. I facilitates hundreds of interactions a year as translator/interpreter and you are encouraged to check websites (American Translators Association, National Board of Certification for Medical Interpreters, ECFMG, Journal of Clinical Investigation, Cancer Cell….) for my license, practice and publications.
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翻译样本