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翻译文本 - English英语 Effects of HBx on the onset of hepatocellular carcinoma and related therapeutic strategies
1. The effects of HBx on the onset of HCC
Studies have shown that HBx is present in both the cytoplasm and the cell nucleus. HBx transactivates the host cell and viral gene promoters through protein-protein interactions and not by direct DNA binding. The activation of the viral gene promoter contributes to the persistence and spread of infection, while the effects of HBx on the host cell genes are much more extensive and profound.
1.1 Cellular oncogene activation.
HBx can activate numerous cellular oncogenes, such as c-myc [9], Src [10], Ras [11], and Rb [12]. HBx activation of these oncogenes has serious implications for the growth and transformation of hepatocytes. Certain oncogenes when activated would also induce the expression of downstream target genes that are intricately linked to cell growth, thereby amplifying their biological effects. For example, Src tyrosine kinases when activated by HBx could further affect the following signaling and response elements: (1) activation of PI-3K [13], (2) activation of STATs [14], (3) activation of β-catenin [15], and (4) suppression of cadherin expression and function [16].
翻译文本 - English英语 The present invention discloses a long-chain recombinant human bone morphogenetic protein-2 (rhBMP-2) and its preparation method and applications. The invention utilizes genetic engineering technology to produce long-chain rhBMP-2 in the Escherichia coli and Saccharomyces cerevisiae expression systems. The invention uses cDNA reverse-transcribed from the mRNA of human sarcoma cells as the template to amplify the nucleotide sequence of the complete 114 amino acids of the naturally occurring mature peptide at its carboxyl terminus, and adds a nucleotide fragment before the first codon at the 5'-end of the forward primer so that the corresponding amino acid sequence would have an added N-terminal polypeptide fragment to produce the long-chain rhBMP-2 gene. Its molecular weight is about 30 kDa, with a purity higher than 95%. The said long-chain rhBMP-2 has high activity, good in vivo stability, and facilitates the expression, renaturation, isolation and purification of the recombinant protein. This promotes in vivo stability of the active protein and stable expression of its activity. It is suitable for filling bone defects, fusing bone grafts, and especially for filling and repairing threaded fusions, delayed healing of fractures, nonunion, and large bone defects.
Malay马来语译成English英语: Information booklet for clinical trial participants Detailed field: 医疗：医药
原文文本 - Malay马来语 Docetaxel digunakan terutamanya dalam rawatan tumor payudara dan paru-paru. Docetaxel ialah satu dari ubat taksana yang pada awalnya dikeluarkan daripada jarum-jarum pokok yew dan tergolong dalam keluarga tumbuhan alkaloid bagi ubat-ubatan kemoterapi. Ia berfungsi dengan menghentikan sel-sel tumor daripada membahagi.
Docetaxel diberikan melalui titisan ke dalam vena (secara intravena). Pemberian titisan tersebut akan mengambil masa kira-kira sejam. Untuk memastikan anda tidak mengalami reaksi alergi terhadap ubat, anda mungkin diberikan tablet steroid selama 12 jam dan 6 jam sebelumnya atau secara intravena selama 30 minit sebelum diberikan ubat. Anda juga akan diberikan antihistamina dan ubat antasid sama ada melalui mulut atau secara intravena sebelum anda diberikan docetaxel.
Kesan sampingan yang dikaitkan dengan mana-mana ubat kemoterapi bergantung kepada individu yang menerima ubatan. Bukan kesemua pesakit akan mengalami kesan sampingan berikut, kebanyakan daripada mereka akan mengalami beberapa kesan sampingan tetapi bukan kesemuanya. Sebahagian besar dari kesan sampingannya adalah buat sementara waktu sahaja dan tubuh anda akan kembali normal selepas rawatan selesai.
翻译文本 - English英语 Docetaxel is used mainly in treating breast and lung cancer. Docetaxel is one of the taxanes initially produced from the needles of the yew tree and belongs to the alkaloid plant family of chemotherapy drugs. It acts by stopping cancer cells from dividing.
Docetaxel is drip-fed into the vein (intravenously). The drip administration takes approximately an hour. To make sure that you do not experience an allergic reaction to the drug, you may be given steroid tablets for 12 hours and 6 hours prior or intravenously for 30 minutes before being given the drug. You should also be given an antihistamine and an antacid drug either orally or intravenously before you are given Docetaxel.
Side effects associated with any chemotherapy drug depend on the individual receiving the drug. Not all patients will experience the following side effects, and most may experience a few but not all of these side effects. Most of the side effects are temporary and your body will return to normal at the end of the treatment.
华为电子科技有限责任公司 (Huawei Technologies Co., Ltd.) - 权利要求书/Patent claims in telecommunications networking. "A method and device for the PVC auto-configuration of an ADSL CPE device" and "A Method for Implementing EAP Authentication Relay in the Wireless Access System". 3497 char total. SinoTrans International, CA, USA.
铁路电力施工规范/Code for construction of railway electric power. 5758 char. JTG, Inc., Alexandria, VA, USA.
诺华中国 (Novartis, People's Republic of China) - 国家食品药品监督管理局技术指导原则 (2State Food and Drug Administration (SFDA) Regulations. 125269 char. ForeignExchange, Providence, RI, USA.
Conference Abstract - "A Comparison Study of the Effect of a Complex and Monotonous Highway Environment on the Weary Driving Behaviour and Work Achievements of the Drivers". 767 char. OxBioSci, UK.
Newspiece - "Scinopharm Taiwan reaps from raw drug materials". 1386 char. OxBioSci, UK.
Institute of Health and Welfare Policy, National Yang Ming University, Taiwan - Research Article "Drug Lag in Taiwan". 6530 char. OxBioSci, UK.
中英审校
i3 Research - Interview transcripts of Depression Patients. 17760 words. TransCom Global Ltd, Tel Aviv, Israel.
Patent in telecommunications networking. "A method and device for the PVC auto-configuration of an ADSL CPE device". 3100 words. SinoTrans International, CA, USA.
Hospira, Inc. - Various academic papers. 11750 words total. Linguistics System, Cambridge, MA, USA.
Paper - "MMP-9 and Cell Migration". Individual client, UK.
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