Glossary entry (derived from question below)
English英语 term or phrase:
off-target activity
Chinese汉语 translation:
脱靶效应
Added to glossary by
peiling
Dec 22, 2006 23:20
17 yrs ago
6 viewers *
English英语 term
off-target activity
English英语译成Chinese汉语
法律/专利
医疗：医药
Text:
To determine whether the non-specific inhibition is due to toxicity of the test compound, an additional cytotoxicity assay may be set up subsequently using the same samples as in the cell-based assay, or separately using the same conditions as the cell-based assay described above. A finding of inhibition of cell proliferation is considered a measurement of off-target activity of the tested compound.
Thank you in advance!
To determine whether the non-specific inhibition is due to toxicity of the test compound, an additional cytotoxicity assay may be set up subsequently using the same samples as in the cell-based assay, or separately using the same conditions as the cell-based assay described above. A finding of inhibition of cell proliferation is considered a measurement of off-target activity of the tested compound.
Thank you in advance!
Proposed translations
+3
45分钟
Selected
脱靶效应
Peer comment(s):
| agree |
Weiping Tang
2小时
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thanks, weiping
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| agree |
pkchan
3小时
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thanks, pkchan
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| agree |
CHEN-Ling
9小时
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thanks, yang min
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4 KudoZ points awarded for this answer.
Comment: "Pei Ling,
Thank you for your help! "
Discussion
http://www.odysseythera.com/news/news.cgi?id=27
top of pg4... "because each siRNA for a given target has the same on-target activity but has different off-target activity."
生物通报道：发表在9月10日的《Nature》和之前的《Nature Methods》的两篇文章首次证明了“脱靶效应（"off-target effects" ，OTEs）”能在长双链RNA ... 脱靶效应沉默了目的靶标之外的基因，长期以来被认为是利用短片段RNA triggers进行RNAi筛选时的难题。 ...
www.ebiotrade.com/newsf/2006-9/200691590151.htm - 27k -
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